spiegelmer technology

A Spiegelmer^® is a mirror-image oligonucleotide that can bind to a pharmacologically relevant target molecule in a manner conceptually similar to an antibody that recognizes an antigen. The mirror image configuration of the oligonucleotide confers tremendous stability in all biological environments, as naturally occurring nucleases cannot degrade Spiegelmers.

Identification of Spiegelmers involves screening of extremely large combinatorial libraries containing over 10¹⁵ different molecules. NOXXON’s technology combines the SELEX process (Systematic Evolution of Ligands by EXponential Enrichment) - the method to screen such a library - with chemical mirroring technology. Employing NOXXON’s technology Spiegelmers can be rapidly generated against a wide variety of target molecules.

Unlike antibodies Spiegelmer are chemical entities unknown to nature and do not require complex biological production processes. Instead Spiegelmers can be synthesized in the laboratory using a process that is easily scalable. NOXXON has established optimized production and quality control methods.

For a summary of Spiegelmer advantages or NOXXON's intellectual poperty estate click on the items on the left.
For a more detailed description of the technology please see:

Publications 

Spiegelmer Technology (720 KB)